Agonist-activated ion channels
نویسندگان
چکیده
منابع مشابه
Agonist-activated ion channels.
This paper looks at ion channels as an example of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked at in this way, ion channels have been helpful because they are still the only system which is simple enough for quantitative investigation of transduction mechanisms. A short history is given of attempts to elucidate what happens between th...
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Mechanotransduction, the conversion of physical forces into biochemical signals, is essential for various physiological processes such as the conscious sensations of touch and hearing, and the unconscious sensation of blood flow. Mechanically activated (MA) ion channels have been proposed as sensors of physical force, but the identity of these channels and an understanding of how mechanical for...
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A. V. Hill was, at the time, an undergraduate of Trinity College Cambridge, though he later held the Chair of Biophysics at University College London, in which job he was succeeded by Bernard Katz. Hill’s ideas were developed over the next 30 years by A. J. Clark (e.g., David Colquhoun* and Bert Sakmann† *Department of Pharmacology University College London Gower Street London WC1E 6BT United K...
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Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the cochlea require elaborate mechanical impedance matching to couple the channels to the external stress. In contrast, MSCs in nonspecialized cells appear activated by stress in the bilayer local to the channel--within about three...
متن کاملStretch activated ion channels in ventricular myocytes.
Patch-clamp recordings from ventricular myocytes of neonatal rats identified ionic channels that open in response to membrane stretch caused by negative pressures (1 to 6 cm Hg) in the electrode. The stretch response, consisting of markedly increased channel opening frequency, was maintained, with some variability, during long (greater than 40 seconds) stretch applications. The channels have a ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2006
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706502